Swallowing Physiology and Impairment in Individuals with.

Dodd, J E (2017) Investigating the functional consequences of widespread RNA dysregulation in TDP-43 related Amyotrophic Lateral Sclerosis cell models. PhD thesis, University of Sheffield. Gibson, Josie (2017) In vivo imaging and analysis of host-pathogen interactions of intracellular pathogens. PhD thesis, University of Sheffield.

Canine degenerative myelopathy(DM) is a late onset neurodegenerative disease that primarily affects German Shepherd dog (GSD), though a number of other specific breeds are also affected. The underlying cause of the disorder remains elusive, though recent advances have implicated a mutation of superoxide dismutase 1(Sod1) in the aetiology, also implying DM is a potential orthologue of human.

PhD Defence of Annelot Dekker. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that leads to progressive muscle wasting and weakness, eventually resulting in swallowing difficulties and respiratory failure.

Medical history has been filled with an array of diseases and illnesses, ranging from the common cold to deadly killers.Some are easily treatable and others can be terminal, but some of the worst are those that still remain without a cure; one such disease is amyotrophic lateral sclerosis.

For the Laboratory for Neuropathology we are looking for a PhD student for experimental neuropathology and cell biology in amyotrophic lateral sclerosis (ALS) The Laboratory of Neuropathology, focusing on the pathogenesis of neurodegenerative disorders, is a growing laboratory in the research group of Experimental Neurology (Neuroscience Department).

Despite more than a century of research, there is still no cure for amyotrophic lateral sclerosis (ALS) and the only available therapeutic extends survival by mere months. The most common motor neuron (MN) disease, ALS is traditionally characterised by selective degeneration of MNs and the systematic destruction of the motor system. However, in the last decade the classification of ALS is.

Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease, and features the select vulnerability of the motor system and degeneration of motor neurons, for which we have no effective cures or treatments. Critical insight as to which processes may underlie disease onset and progression have come from studies identifying.

Amyotrophic lateral sclerosis (ALS) is a devastating neuromuscular disorder characterized by degeneration of lower and upper motor neurons. The incidence ranges from 1.5 to 2.0 per 100,000 population per year with an overall male predominance. The course of the disease is relentlessly progressive, but the rate of deterioration varies from.

The Department of Medical Epidemiology and Biostatistics (MEB) is among the largest departments of epidemiology in Europe with special focus on increasing our knowledge of the aetiology of different diseases. Our department consists of researchers, doctoral students, biostatisticians, data collectors and database administrators as well as administrative personnel, in total.

Physiopathology of the amyotrophic lateral sclerosis: implication of the neuromodulatory systems in the spinal motor netwoks. Defended on December 10, 2014. Abstract. Neuromodulatory systems play a crucial role in the establishment and regulation of spinal motor.

DNA sequence variants in the TBK1 gene associate with or cause sporadic or familial amyotrophic lateral sclerosis (ALS). Here we show that mice bearing human ALS-associated TBK1 missense loss-of.

Neurodegenerative diseases, especially amyotrophic lateral sclerosis and Parkinson's disease. Psychological stress and its related health outcomes, including cardiovascular diseases, mental disorders, and cancer. Distinctions and Awards. Strategic Research Area (SFO) Epidemiology Senior Researcher Award at the Karolinska Institutet, 2016.